It happened on Palm Avenue near Fountain Way around 11:30 pm Sunday.
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Fresno Police responded to the area after receiving a report of an injured man lying on the road.
Officers arrived and determined he was riding a bicycle when he was hit by a car.
The bicyclist was rushed to the hospital, where he is in critical condition.
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Fresno Police officers are now searching for the driver.
Anyone with information is asked to contact Fresno Police.