It was first reported just after 11 pm Thursday in a strip mall on the northwest corner of Cedar and Shields.
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Firefighters responded for smoke coming from the building.
They were told people were inside, but after a search, no one was found.
Firefighters say debris was burning inside the vacant store.
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It's believed unhoused people may have been inside the building before the fire.
The flames did not spread to the building itself.
No one was hurt.