(The video above is from an earlier story and will be updated.)
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The crash happened just at 5:20 a.m. on Highway 180 and Siskiyou Avenue.
Fresno County Sheriff's Office said one of his deputies was driving eastbound while on patrol when he struck an unhoused woman crossing the roadway.
The woman was hit in an unlit portion of the Highway and it's believed she was collecting cans in the area.
The deputy pulled over immediately to provide medical aid but she died at the scene.
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The unhoused woman has not yet been identified and it's believed she was 60 years old.
There is a hard closure at Modoc and Siskiyou Avenues and drivers are being advised to find alternate routes.
Stay with ABC30 for the latest details on this developing story.