The Farmersville Unified School District says about 43 students reported feeling sick at Freedom Elementary School.
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Officials say the children described feeling nauseous, dizzy, and numb in their mouths and fingers.
In a message from the school, they informed parents that emergency responders were checking on the students but that the campus would be locked down.
A majority of the students were taken to local hospitals to be evaluated.
Parents picked up the other sick children.
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Officials believe something the students ate made them sick.
The school cafeteria has shut down as Tulare County health officials investigate.
School is set to resume on Thursday.