It happened just after 6:30 am on Elm Avenue north of Manning Avenue, south of Easton.
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Investigators believe the woman tried to make a U-turn when she lost control of the vehicle. The victim tried to get out, but the car crashed into a tree, leaving the driver pinned between her car and the door.
She was pronounced dead at the scene.
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The CHP is working to determine whether the driver may have suffered a medical emergency. Her name has not been released.