The Fresno County Department of Public Health says the first death was an elderly person who caught the flu.
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Since then, three more deaths related to the flu have been reported in the county.
The department says it suspects a fifth death is also flu-related, but they are still working to confirm that.
Officials are now encouraging everyone who is six months and older to get their flu vaccinations.
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Those who have any respiratory symptoms are urged to stay at home and test for the flu and COVID-19.
The health department is still offering vaccines for this flu season.
For more information on getting a vaccine, call (559) 600-3550 or click here.