The man, identified as 33-year-old Allen Michael Alaniz, was driving on a suspended license due to a prior DUI and he had been on parole for attempted murder, police say.
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The incident happened in the area of Tulare Street and U Street Thursday evening.
Police said the Alaniz was open to search and seizure, which is when they found a black plastic bag containing the blue pills.
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The suspect has been booked in Fresno County Jail and the vehicle was impounded for evidence, police say.