It happened after 12:30 am on Friday at the intersection of Mendocino and Dinuba.
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CHP officers say the driver of the semi rolled a stop sign and collided with a pickup truck.
"It appears he hit the driver's side rear portion of the cab, which turned the cab and spun it around, and he had been jack-knifed as we see him," said Sgt. Garrett Peck.
The driver of the pickup, who is said to be in his 40s, suffered minor injuries and was taken to a local hospital.
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Officers said he was wearing his seatbelt.
The driver of the semi is okay.