It happened on Floral at Alta Avenues, just north of Dinuba, at about 4 pm Sunday.
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Officers say 24-year-old Jessica Guerra of Selma was driving a Chevy Malibu west on Floral when she ran a stop sign and was hit by a Ford Expedition.
The Chevy was spun around and rolled over, landing on its roof in a canal.
Officers say Guerra and a 43-year-old passenger were not wearing seat belts and had to be flown by helicopter to the hospital for their injuries.
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Three others were taken by ambulance for minor injuries.
All of them are expected to survive.
Guerra was placed under arrest for driving under the influence of alcohol.