In a statement, Jennifer Aniston, Courteney Cox, Lisa Kudrow, David Schwimmer and Matt LeBlanc wrote: "We are all so utterly devastated by the loss of Matthew. We were more than just cast mates. We are a family."
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"There is so much to say, but right now we're going to take a moment to grieve and process this unfathomable loss."
"In time we will say more, as and when we are able," the statement adds. "For now, our thoughts and our love are with Matty's family, his friends, and everyone who loved him around the world."
Matthew Perry remembered: Hollywood community pays tribute to late 'Friends' star
Actors, fans pay tribute to Matthew Perry after actor's death at 54
Perry died Saturday at his home in the Los Angeles area. He was 54.
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Police say there were no obvious signs of foul play at the scene.
The coroner's office is listing Perry's cause of death only as "deferred" for now until toxicology tests are completed, which could take weeks.
Tributes have poured in for the beloved actor who portrayed Chandler Bing on the decade-long run of the popular NBC sitcom, "Friends."
Matthew Perry autopsy completed: LA County coroner
After the show ended Perry transitioned to a film career with features such as "The Whole Nine Yards" and "Fools Rush In."
He also documented his struggles with substance abuse, which led to personal health crises, but has said he was sober in recent years. He released a memoir last year titled "Friends, Lovers and the Big Terrible Thing."