The incident happened at the intersection of Highway 180 and Oliver Street on Saturday afternoon.
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Authorities say the victim, 60-year-old Israel Lara from Sanger, was driving a grey Ford Focus southbound on Oliver.
According to witnesses, Lara ran the stop sign on Oliver and entered westbound Highway 180.
A yellow Ford Econoline van traveling westbound on the highway swerved to avoid him and hit a white Hyundai Tucson.
It then spun, overturned, and came to rest on the north shoulder.
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The white Tucson then collided with the Ford Focus, severely injuring Lara who died at the scene.
Authorities say they are investigating the possibility of a DUI.
All other people involved in the crash sustained minor injuries.
This story is developing and will be updated.