The crash happened at 6:30 pm on Sunday near Mount Whitney Avenue just outside Riverdale.
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California Highway Patrol officers say the driver slammed into the concrete divider. The semi exploded following the collision.
The driver was able to escape without being injured.
The big rig was hauling pizza cheese. Several boxes and pallets were scattered across the northbound lane of the highway.
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Crews spent several hours overnight clearing the debris. Both lanes were reopened to traffic by 5 am on Monday.
The cause of the crash is still under investigation.