West appeared to reignite a feud with the fellow rapper in a series of tweets on Thursday in which he claimed Drake had called trying to threaten him.
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West wrote "So drake if anything happens to me or anyone from my family you are the first suspect - So cut the tough talk."
West alleged Drake was behind audience members rushing the stage and splashing fellow rapper Pusha T with liquid during a concert in Toronto in November.
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Drake did not post a response. An email seeking comment was sent to a Drake representative.
The rappers have had an ongoing feud this year, but West had apologized to Drake in September.