The reality star posted about her and daughter True's positive COVID-19 results Friday and said she is vaccinated.
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The third-oldest celebrity sibling in the Kardashian-Jenner family also said she "had to cancel several commitments."
"We will be over here in quarantine and following current guidelines," the tweet read.
Kardashian was first diagnosed with COVID-19 in March of 2020 and documented her illness in a "Keeping Up with the Kardashians" episode that aired in fall 2020.
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Kardashian said her symptoms included coughing, shaking, vomiting, headaches along with cold and hot flashes. She said she had a burning sensation while coughing.
"I have been in my room," she said in the episode. "It's gonna be fine, but it was really bad for a couple days."
The Associated Press contributed to this report.