The Fresno Fire Department was called out to a home on North Vagedes Avenue, near Fruit and Olive, around 7:30 p.m. Sunday.
When crews arrived, they found one home engulfed in flames and a home next door with some fire damage.
The extent of the fire and the warm temperatures prompted a second alarm response. At least 50 firefighters were called to fight the flames.
Officials say a dog and a cat were rescued from the home, and no one was injured.
The cause of the fire remains under investigation.
Stay with ABC30 for the latest details on this developing story.