Police say they were called to the crash on Sunnyside Avenue and Chinowth Street just after 2 p.m.
Before officers arrived, they were informed the driver had fled the scene.
Investigators say a car sped through a nearby home's yard, hit a fence and crashed into a parked car before colliding into another home across the street.
Both the driver and passenger were later found and arrested.
Police say the driver faces felony DUI and hit-and-run charges. The passenger was arrested for outstanding warrants.
One person inside the home was taken to the hospital with non-life-threatening injuries.
Stay with ABC30 for the latest details on this developing story.