The stabbing happened around 7 pm in the area of the St. John's Bridge and Ben Maddox Way in Visalia.
The Tulare County Sheriff's Office says deputies found an unresponsive man and a woman who had been stabbed in the neck.
It's unclear whether the man had also been stabbed.
They were both taken to a local hospital, where their conditions are currently unknown.
Investigators have not yet shared any other details about the stabbing.