The Fresno County Sheriff's Office arrested 26-year-old Erik Madrigal Garcia and 27-year-old Jonathan Morales Ramos on murder charges.
Ramos is currently in prison for another crime.
In January 2016, deputies found 31-year-old Alfonso Barbosa and 29-year-old Fray Martin Rodriguez shot dead.
The victims were discovered in a car left running on the side of the road near Dinuba and Crawford Avenues -- just east of Reedley.
After years of investigating, detectives identified Garcia and Ramos as suspects.
Investigators believe the two victims were targeted for their involvement in gang activity.