The crash forced a portion of northbound 99 to shut down for several hours.
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It happened before 5pm on the 99, just north of Highway 41.
The California Highway Patrol says two big rigs and a Ford F-250 utility truck were involved in the collision.
The pickup driver had to be extricated from the truck.
He was taken to the hospital.
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At last check, he is in critical condition.
Authorities have not released what led up to the crash.
Stay with Action News for the latest updates on this developing story.