The California Highway Patrol says the crash happened just before 5 am on Road 9 and Avenue 25, just west of Chowchilla.
Officers say a woman was driving a Nissan Altima south on Road 9 when she drove past a stop sign at the intersection with Avenue 25.
A Toyota Tacoma was going west and crashed with the side of the Altima.
The woman was declared dead at the scene. Officers say she was not wearing a seatbelt.
The driver of the Tacoma complained of pain but was not taken to the hospital.
Officers say drugs or alcohol do not appear to be factors.