It happened just after 6 p.m. at the Palm Springs Festival of Lights Parade.
According to a statement issued by the city, the crash happened along the parade route.
Ten people, including the officer, were rushed to the hospital with non-life threatening injuries, the city said.
The California Highway Patrol is investigating the incident and is requesting video and images be emailed to PSCityGovernmentMedia@palmspringsca.gov.
"We appreciate the community's support and our thoughts are with the officer, his family and all of those injured today," read the city's statement.
The incident remains under investigation.