The Fresno County Coroner's Office has identified him as 27-year-old Roberto Vasquez II of Fresno.
California Highway Patrol officers responded to the crash on South Goldenrod and West Jensen avenues Sunday afternoon.
Officers say a man, now identified as Vasquez, was driving a white Toyota Tundra when he ran the stop sign on Jensen Avenue and T-boned a car carrying a mother and her two infant children.
Both cars rolled off the road from the impact of the crash.
The mother and her kids were taken to the hospital with minor to moderate injuries.
Officers say alcohol does not appear to be a factor in the crash.