Police responded to reports of a large fight at an apartment complex on North Divisadero Street on Sunday.
When officers arrived, they found a 54-year-old man unconscious and a 28-year-old man both with injuries from physical assault.
Both victims were taken to the hospital, where the 54-year-old later died from his injuries.
The Violent Crimes Unit took over the investigation, leading to the arrests of 29-year-old Oscar Medrano of Visalia and 24-year-old Mario Lopez of Corcoran.
Both suspects have now been charged with homicide and were booked into the Tulare County Adult Pre-Trial Facility.
Anyone with more information is asked to contact Visalia police.