According to a statement shared on her official Instagram account, Paquita, whose real name was Francisca Viveros Barradas, died in her home in Veracruz, Mexico.
It's unclear how she died.
Paquita was best known for hit songs like "Rata de dos Patas," a widely known scorned-lover song about a cheating ex.
Paquita la del Barrio fans react to the Mexican singer's death
Paquita la del Barrio fans react to the Mexican singer's death
Just a few weeks ago, the singer had to postpone her show at the National Auditorium in Mexico City due to immobility in her legs.
Paquita broke barriers in the Mexican ranchera genre, which is typically dominated by men.
For many, she was the "queen and defender of women" as her songs often talked about female empowerment.