According to a spokesperson, Kellerman died in her sleep due to heart failure at her home in Woodland Hills.
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Kellerman's role in "M*A*S*H" earned her an Oscar nomination for Best Actress in a Supporting Role.
Sally Kellerman as 'Hot Lips' Houlihan in 'M*A*S*H'
Her career spanned more than 60 years in television and film, including the original pilot for "Star Trek," the films "Back to School" and several other Altman films including "Welcome to L.A.," "The Player," and "Pret-a-Porter."
Most recently, she starred in the 2016 television series "Decker" and "Maron."
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In 2014, she was nominated for an Emmy as "Outstanding Best Guest Performer" for her appearances on "The Young and Restless."
Kellerman was born in Long Beach. She is survived by her son Jack, daughter Claire and mother-in-law Lorraine Krane.