It happened Monday after 9:30 am near Highway 201 and Road 116.
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Officers say the 37-year-old rider crashed into a tree in a nearby orchard. He died at the scene.
The CHP says the rider was a man from Dinuba. His name has not been released.
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Investigators are working to determine what caused the man to crash his bike.
It's unclear if drugs or alcohol were factors in the crash.