CHP officers say an 18-year-old driver of a 2007 Hyundai was traveling north on Highway 99 when he crashed into the back of a trailer being hauled by Aurelio Castaneda's truck.
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The driver and his 24-year-old passenger died on impact. Their names have not been released.
Officials say Castaneda drove away after the crash, leaving the Hyundai in the northbound lane.
Minutes later, a woman driving northbound on the highway crashed into the Hyundai. Officers say the Hyundai's third male passenger, 20-year-old Adonis Malik Jones, suffered major injuries in both crashes and was rushed to a local hospital.
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The woman suffered minor injuries.
Officers found Castaneda a short time later and arrested him for hit-and-run.
CHP says they have not yet ruled out DUI as a possible factor in the crash.