The Learjet 55 crashed after departing from Northeast Philadelphia Airport.
PHILADELPHIA -- A small medical transport plane, carrying a pediatric patient and five other people, crashed in Philadelphia on Friday, officials said, with a fiery explosion observed upon impact.
The Learjet 55 crashed near the Roosevelt Mall in northeast Philadelphia around 6:30 p.m. after departing from Northeast Philadelphia Airport, according to the Federal Aviation Administration.
There is no word yet on injuries or deaths.
Speaking at a news conference shortly after 8:30 p.m., Philadelphia Mayor Cherelle Parker said officials could not yet provide a number of fatalities. "Right now, we're just asking for prayers," she told reporters.
Several homes and vehicles were impacted by the crash, said the mayor who urged residents to stay away from the scene.
VIDEO: Moment of impact caught on camera after plane crash in Northeast Philadelphia
A large fire burned in the wake of the crash, prompting a significant response.
There were six people on board the aircraft, according to the Federal Aviation Administration.
The company that operated the flight, Jet Rescue Air Ambulance, said in a statement there were four crew members on board, along with the pediatric patient and an escort.
"At this time, we cannot confirm any survivors," the company said in the statement. "No names are being released at this time until family members have been notified. Our immediate concern is for the patient's family, our personnel, their families and other victims that may have been hurt on the ground."
The air ambulance plane was en route to Springfield-Branson National Airport in Missouri, according to Flight Radar24 data
The FAA and the National Transportation Safety Board are investigating.
VIDEO: Destroyed vehicles, other debris seen after plane crash in Northeast Philadelphia
The Philadelphia Fire Department advised residents to avoid the area of Calvert and St. Vincent streets.
The FAA issued a ground stop at Northeast Philadelphia Airport due to "an aircraft incident."
Transportation Secretary Sean Duffy said he is monitoring the crash and heading to the FAA to get information.
Pennsylvania Gov. Josh Shapiro said his team is communicating with local officials and first responders and is "offering all Commonwealth resources as they respond to the small private plane crash in Northeast Philly."
The FAA had initially reported there were two people on board the aircraft but later corrected that report.
ABC News' Ayesha Ali and Sam Sweeney contributed to this report.
This is a developing story. Please check back for updates.