It happened just before 11 am Wednesday near Barstow and Stanford.
Officers say a woman driving a red SUV made a left turn, colliding with a motorcyclist.
EDITOR'S NOTE: The video above is from a previous broadcast and will be updated.
The man on the bike was killed, and the female driver was arrested for DUI.
Barstow was closed for a few hours while police investigated the crash.
The motorcyclist's identity has not yet been released.